Skin Based Delivery Systems for Therapeutic Molecules: Advancing Dermatological Treatments through Innovative Drug Delivery Technologies

¹Idaho College of Osteopathic Medicine, Meridian, ID, USA

²Des Moines University College of Osteopathic Medicine, West Des Moines IA, USA

³Meharry Medical College, Nashville TN, USA

⁴California Health Sciences University College of Osteopathic Medicine, Clovis CA, USA

⁵Wake Forest University School of Medicine, Winston-Salem NC, USA

⁶Drexel University College of Medicine, Philadelphia PA, USA

⁷Department of Dermatology, Northwell Health, New Hyde Park NY, USA

*Corresponding author: Kelly Frasier, DO, MS, Department of Dermatology, Northwell Health, New Hyde Park, NY, USA, Phone: 3105956882, Email: [email protected]

Received Date: February 09, 2025

Publication Date: February 21, 2025

Citation: Owsley A, et al. (2025). Skin Based Delivery Systems for Therapeutic Molecules: Advancing Dermatological Treatments through Innovative Drug Delivery Technologies. Dermis. 5(1):30.

Copyright: Owsley A, et al. © (2025).

ABSTRACT

The skin, recognized as the body's largest organ, plays a dual role as both a protective barrier and a vital conduit for transdermal therapeutic interventions. Recent decades have witnessed significant progress in the realm of skin based drug delivery systems, fundamentally transforming the administration of dermatological treatments. Traditional delivery methods, including oral medications and injectable therapies, frequently confront challenges such as diminished bioavailability, delayed therapeutic onset, and systemic side effects. In contrast, skin based delivery systems present a compelling alternative by facilitating the direct application of therapeutic agents at the targeted site of action, thereby minimizing systemic exposure and optimizing localized effects. Beyond their applications in dermatology, skin based delivery systems hold promise for the management of systemic conditions that manifest with cutaneous symptoms. Diseases such as rheumatoid arthritis, diabetes, and certain malignancies often present with dermatological manifestations, and localized delivery of systemic treatments via the skin could provide a more efficient and less invasive approach to managing these conditions. This review aims to explore the burgeoning field of skin based delivery systems for therapeutic molecules, with a particular emphasis on the utilization of nanotechnology, microneedles, and other innovative delivery methodologies in dermatology.

Keywords: Transdermal Drug Delivery, Skin-Based Therapies, Nanotechnology, Cutaneous Manifestations, Drug Administration, Medical Applications, Therapeutic Agents